Xantina desidrogenase

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Xantina desidrogenase
Renderização com base em PDB 1fiq.
Estruturas disponíveis PDB Busca de ortólogos: PDBe, RCSB Lista de códigos PDB 2CKJ, 2E1Q
Identificadores
Símbolos	XDH; XO; XOR
IDs externos	OMIM: 607633 MGI: 98973 HomoloGene: 324 ChEMBL: 1929 GeneCards: XDH Gene
Número EC	1.17.3.2 1.17.1.4, 1.17.3.2
Ontologia do gene Função molecular •xanthine dehydrogenase activity •xanthine oxidase activity •iron ion binding •UDP-N-acetylmuramate dehydrogenase activity •electron carrier activity •protein homodimerization activity •molybdopterin cofactor binding •flavin adenine dinucleotide binding •2 iron, 2 sulfur cluster binding Componente celular •extracellular space •peroxisome •cytosol Processo biológico •negative regulation of protein phosphorylation •negative regulation of endothelial cell proliferation •purine nucleobase metabolic process •purine nucleotide catabolic process •activation of cysteine-type endopeptidase activity involved in apoptotic process •lactation •xanthine catabolic process •negative regulation of gene expression •small molecule metabolic process •negative regulation of endothelial cell differentiation •negative regulation of protein kinase B signaling •nucleobase-containing small molecule metabolic process •oxidation-reduction process •positive regulation of p38MAPK cascade •negative regulation of vascular endothelial growth factor signaling pathway •positive regulation of reactive oxygen species metabolic process •negative regulation of vasculogenesis Sources: Amigo / QuickGO
Padrões de expressão do ARN
Mais dados de expressão
Ortólogos
Espécies	Humano	Rato
Entrez	7498	22436
Ensembl	ENSG00000158125	ENSMUSG00000024066
UniProt	P47989	Q00519
RefSeq (mRNA)	NM_000379	NM_011723
RefSeq (proteína)	NP_000370	NP_035853
Localização (UCSC)	Chr 2: 31.56 – 31.64 Mb	Chr 17: 73.88 – 73.95 Mb
Busca PubMed	[1]	[2]

Xantina desidrogenase, também conhecimento como XDH, é uma proteina que em humanos, é codifcado pelo gene XDH.